Diego Luna
Manolo (voice)
Channing Tatum
Joaquin (voice)
Zoe Saldaña
Maria (voice)
Christina Applegate
Mary Beth (voice)
Eugenio Derbez
Chato (voice)
Cheech Marin
Pancho Rodriguez (voice)
Gabriel Iglesias
Pepe Rodriguez (voice)
Ron Perlman
Xibalba (voice)
Kate del Castillo
La Muerte (voice)
Ana de la Reguera
Carmen Sánchez (voice)
Dan Navarro
Chakal (voice)
Ice Cube
Candle Maker (voice)
Héctor Elizondo
Carlos Sanchez (voice)
Danny Trejo
Skeleton Luis (voice)
Carlos Alazraqui
General Posada / Dali / Chuy (voice)
![Emil-Bastien Bouffard]()
Emil-Bastien Bouffard
Young Manolo (voice)
Elijah Rodriguez
Young Joaquin
![Genesis Ochoa]()
Genesis Ochoa
Young Maria (voice)
Plácido Domingo
Skeleton Jorge (voice)
Grey DeLisle
Grandmother (voice) (as Grey Griffin)
![Trey Bumpass]()
Trey Bumpass
Goth Kid / Orphan
Miguel Sandoval
Land of the Remembered Captain (voice)
Ben Gleib
Goya / Dali (voice)
![Ricardo El Mandril Sanchez]()
Ricardo El Mandril Sanchez
Pablo Rodriguez (voice)
![Ishan Sharma]()
Ishan Sharma
Sanjay
Jorge R. Gutierrez
Skeleton Carmelo (voice)
Anjelah Johnson-Reyes
Adelita / Nina (voice)
![Kennedy Peil]()
Kennedy Peil
Sasha (voice)
Sandra Equihua
Scardelita (voice)
![Callahan Clark]()
Callahan Clark
Jane (voice)
Gunnar Sizemore
Ignacio (voice)
Angélica María
Sister Ana (voice)
Eric Bauza
Father Domingo / Cave Guardian (voice)
Aron Warner
Thomas (voice)
Sandra Echeverría
Claudia (voice)
Tonita Castro
La Muerte as Old Woman (voice)
Troy Evans
Old Man Hemingway (voice)
Guillermo del Toro
Land of the Remembered Captain's Wife (voice)
Brad Booker
Conductor (voice)
Rosemary Alexander
Additional Voices (voice)
Steve Alterman
Additional Voices (voice)
Eva Bella
Additional Voices (voice)
![Madison Carlon]()
Madison Carlon
Additional Voices (voice)
Vicki Davis
Additional Voices (voice)
Moosie Drier
Additional Voices (voice)
Cullen McCarthy
Additional Voices (voice)
David Michie
Additional Voices (voice)
![Michelle Moores]()
Michelle Moores
Additional Voices (voice)
Jonathan Nichols-Navarro
Additional Voices (voice)
Al Rodrigo
Additional Voices (voice)
Marcelo Tubert
Additional Voices (voice)
Lynnanne Zager
Additional Voices (voice)
Ruth Zalduondo
Additional Voices (voice)
Newell Alexander
Additional Voices (voice)
David Cowgill
Additional Voices (voice)
Elisa Gabrielli
Additional Voices (voice)
Richard Miro
Additional Voices (voice)
Arthur Ortiz
Additional Voices (voice)
![Nathaniel Semsen]()
Nathaniel Semsen
Additional Voices (voice)
Joe Matthews
Young Manolo (singer)
Jose Alvarez
Additional Voices (voice) (uncredited)
